Cell-based Therapy For Myocardial Regeneration

Cell-based Therapy For Myocardial Regeneration ABSTRACT Myocardial infarction is one of the main cause of mortality in many countries. Therefore, an effective therapy for myocardial infarction is required. Reperfusion and other conventional therapy have been the mainstay therapy for myocardial infarction. However, many patients remain refractory to this therapy. Cell-based therapy is considered a novel therapy, in which stem cells are used for cardiac repair. Stem cells are potential therapeutic and promising option that could be the alternative solution for salvaging damaged cardiomyocyte. Based on current studies, stem cells are a promising therapeutic approach for myocardial infarction. However, some challenges need to be answered by future studies before this novel therapy can be widely applied. This essay provides an overview of the progress in stem cell therapy for myocardial infarction. INTRODUCTION The robust potential of stem cells were still a mystery, but today, we are constantly getting new information on this parti cular topic. One of the prospects of stem cell therapy is to treat damaged cardiomyocyte (Fischer, et.al, 2009; Beltrami, 2003).Acute myocardial infarction is one of the main causes of mortality and morbidity in many countries. Not only this disease causes a massive socio-economic burden, but also reduces the quality of live for patients who survive the attack (Hamm, 2016). Currently, one of the mainstay therapy for myocardial infarction is rapid revascularization to limit ischaemic damage. Reperfusion and other conventional therapy have undoubtedly saved so many lives, yet there are patients remained refractory to this therapy and left with no other treatment options. In addition to that, many patients who have underwent reperfusion strategy and survived, often left with significant impairment of left ventricular systolic function. One big question remain unanswered. Is there any other treatment option for these patients? Medical therapeutic approach to reduce damaged cardiomyocyte and generate new functioning muscle is the current unmeet need. Stem cells emerge as the novel procedure to restore damaged cardiomyocytes, and this procedure is popularly known as cellular cardiomyoplasty (Pendyala, et.al, 2008; Reinlib, 2000). Many preclinical and clinical trials have documented the potential use of stem cells to generate viable cardiomyocyte and improve cardiac function (Bergmann, et.al, 2009). To date, there are many different types of adult stem cells and progenitor cells used for this procedure, some of which are bone marrow derived stem cells, hematopoietic stem cells, mesenchymal stem cells and so on. Since the advance of stem cells technology is faster than ever before, this essay aimed to give an evidence based update on stem cells use for myocardial infarction, what we have achieved so far, and what does the future hold for this breakthrough. CELL-BASED THERAPY FOR MYOCARDIAL REGENERATION After an ischaemic attack due to occluded coronary vessels, heart muscle usually left damaged and nonfunctioning. However, recent evidence suggested that the cardiac muscle could actually undergo a limited amount of renewal. A prospect of inducing muscle cell to undergo division for cardiomyocyte replacement, or generating new muscle by stem cells are certainly intriguing (Roell, et.al, 2002; Santoso, et.al, 2011). Stem cells are capable to proliferate in the same state (self-renewal) and differentiate into multiple cell lineages. On the other hand, progenitor cells are more specific and have limited differentiation potential. Mechanism on how stem cells work are as follows: firstly, these stem cells need to be extracted from the source (eg. bone marrow), after that these stem cells need to be delivered to the injured area. These cells are implanted in the myocardium, and due to the nature of these cells, they would grow and differentiate/transdifferentiate into cardiomyocyte. To achieve the goal of cardiac repair, these cells should also have the ability to fuse with the surrounding tissues that their harmonious contraction increases the heart contraction. Furthermore, these newly-formed cardiomyocyte should also express the appropriate electromechanical properties required for contraction to yield a synchronous contraction (Templin, et.al, 2011; Makino, et.al, 1999).

E-Recruitment in the banking Industry a comparative study in to the UK Dissertation

E-Recruitment in the banking Industry a comparative study in to the UK bank Lloyds TSB and Indian bank ICICI - Dissertation Example A primary research study which is composed of a combination of quantitative research survey and research interview was conducted to determine the factors that could significantly influence the e-recruitment practices in both banks. Based on the research findings, the three (3) significant factors that can affect the ability of the banks to maximize the full benefit of its e-recruitment practices includes: the unique recruitment practices in each bank, access to Internet, and the ability of the people to use the computers. To make Lloyds TSB and ICICI be able to maximize its full investment on e-recruitment platform, this study highly recommends the idea that the bank manager(s) should be able to design and implement strict policies with regards to the use of the banks’ e-recruitment process. In the case of Lloyds TSB, its bank personnel should redesign the banks’ existing e-recruitment practices to be more friendly in the sense that it should allow the bank personnel to get to know each candidate on a personal level. In the case of ICICI, its existing e-recruitment process is not highly dependent over the use of its official website. For this reason, one of the best ways to improve ICICI’s existing e-recruitment is for the bank to offer better online forms. Other study recommendation includes the need to simplify the online testing. Through the use of basic and simple IQ test, maths test, or English, the banks will have lesser risks of screening out individuals with positive work attitude and pleasing attitude and personality needed in serving the bank customers. It is also necessary to keep the actual design of the virtual recruiting environment simple and user-friendly. SPECIMEN ABSTRACT STUDENT NAME Kirandeep KAUR DEGREE MBA International Business DISSERTATION SUPERVISOR Richard Knight DISSERTATION TITLE E-Recruitment in the banking Industry a comparative study in to the UK bank Lloyds TSB and Indian bank ICICI DATE September 3rd 2012 KE YWORDS E-RECRUITMENT CULTURE RECRUITMENT METHODS ABSTRACT E-recruitment is pertaining to the use of information technology in the recruitment processes of each bank. Through the strict implementation of e-recruitment, each bank can speed up and improve the overall quality of the banks’ recruitment services. Banks like Lloyds TSB in UK and ICICI in India spent a lot of money on its e-recruitment platform. Among the common reasons why these two banks invested on e-recruitment is to get hold of the most highly competitive individuals to join the team, speed up, and further improve its existing recruitment services. A primary research study which is composed of a combination of quantitative research survey and research interview was conducted to determine the factors that could significantly influence the e-recruitment practices in both banks. Based on the research findings, the three (3) significant factors that can affect the ability of the banks to maximize the full benefit of its e-recruitment practices includes: the unique recruitment practices in each bank, access to Internet, and the ability of the people to use the computers. To make Lloyds TSB and ICICI be able to maximize its full investment on e-recruitment platform, this study highly recommends the idea that the bank manager(s) should be able to design and implement

How would you describe the expansion of the United States between 1783 Research Paper

How would you describe the expansion of the United States between 1783 and 1840s - Research Paper Example The expansion that took place in the period between 1783 and 1840 is the reason behind the large size of the USA and its current strong economic position. Is also led to the end of slave trade in the USA The first expansion of the USA took place in 1783 after the treaty of Paris which brought to an end the revolutionary war. England agreed to the claims of the Americans to own the southern land which included the great lakes and the Mississippi river (Rothman 57). The Americans were not successful in getting the Gulf of Mexico, and it remained under ownership of Spain. The next expansion of the United States took place in 1787 whereby the US expanded with the Northwest ordinance of 1787 (Rothman 116). This ordinance established the Northwest Territory, which covered states such as of Illinois, Indiana, Michigan, Ohio, and Wisconsin. The expansion is renowned for having banned slavery in the north of Ohio River. In 1803, President Thomas Jefferson talked terms of the purchase of the French claims on the Louisiana territory which they had previously obtained from the Spain. The negotiations were secret, and it is believed that the president purchased the territory at a price of $15million. The land purchased included the western half of the Mississippi river, and it doubled the initial size of the USA. The purchase also extended to the Gulf of Mexico, which was very productive in agriculture. Settler’s movement to the Louisiana territory raised the question of slave trade. The settlers applied for statehood after reaching a number of 60000 and in 1819, it officially became a slave state (Morgan 34). Before 1810, the country had occupied most parts of the Mississippi river but had little control over its mouth which was located in the Spanish Florida (Shelly 239). In 1810, the United States seized the western part of Florida, and it led to the outbreak of war between the Spaniards and the Americans (Smith 17). However, the Spaniards relented since